InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR1B

Summary

InnateDB Protein

IDBP-93322.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR1B

Protein Name

5-hydroxytryptamine (serotonin) receptor 1B

Synonyms

5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12;

Species

Homo sapiens

Ensembl Protein

ENSP00000358963

InnateDB Gene

IDBG-93320 (HTR1B)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1315531, ECO:0000269PubMed:1328844, ECO:0000269PubMed:1348246, ECO:0000269PubMed:1351684, ECO:0000269PubMed:1559993, ECO:0000269PubMed:1565658, ECO:0000269PubMed:15853772, ECO:0000269PubMed:1610347, ECO:0000269PubMed:23519210, ECO:0000269PubMed:23519215, ECO:0000269PubMed:8218242}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1315531, ECO:0000269PubMed:1328844, ECO:0000269PubMed:1348246, ECO:0000269PubMed:1351684, ECO:0000269PubMed:1559993, ECO:0000269PubMed:1565658, ECO:0000269PubMed:1610347, ECO:0000269PubMed:23519210, ECO:0000269PubMed:23519215}; Multi-pass membrane protein {ECO:0000269PubMed:10452531, ECO:0000269PubMed:1315531, ECO:0000269PubMed:1328844, ECO:0000269PubMed:1348246, ECO:0000269PubMed:1351684, ECO:0000269PubMed:1559993, ECO:0000269PubMed:1565658, ECO:0000269PubMed:1610347, ECO:0000269PubMed:23519210, ECO:0000269PubMed:23519215}.

Disease Associations

Tissue Specificity

Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269PubMed:1348246, ECO:0000269PubMed:1351684, ECO:0000269PubMed:15853772}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0002031	G-protein coupled receptor internalization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007631	feeding behavior
GO:0014059	regulation of dopamine secretion
GO:0014063	negative regulation of serotonin secretion
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0035690	cellular response to drug
GO:0042220	response to cocaine
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0042756	drinking behavior
GO:0045471	response to ethanol
GO:0046849	bone remodeling
GO:0050795	regulation of behavior
GO:0051385	response to mineralocorticoid
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0071312	cellular response to alkaloid
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002147 5-Hydroxytryptamine 1B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00513
PR01101
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28222