InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHIP

Summary

InnateDB Protein

IDBP-93360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHIP

Protein Name

pleckstrin homology domain interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000275034

InnateDB Gene

IDBG-93358 (PHIP)

Protein Structure

UniProt Annotation

Function

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti- apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269PubMed:12242307, ECO:0000269PubMed:21834987}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in myeloma and epidermoid carcinoma cell lines. {ECO:0000269PubMed:11018022}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006606	protein import into nucleus
GO:0007010	cytoskeleton organization
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0022604	regulation of cell morphogenesis
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0040008	regulation of growth
GO:0043066	negative regulation of apoptotic process
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway