Version 5.4
Homo sapiens Protein: ENTPD8
Summary
InnateDB Protein IDBP-93365.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD8
Protein Name ectonucleoside triphosphate diphosphohydrolase 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360561
InnateDB Gene IDBG-93363 (ENTPD8)
Protein Structure
UniProt Annotation
Function Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. {ECO:0000269PubMed:16752921, ECO:0000269PubMed:17095758}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0009124 nucleoside monophosphate biosynthetic process
GO:0009133 nucleoside diphosphate biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000407 Nucleoside phosphatase GDA1/CD39
PFAM PF01150
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5MY95
PhosphoSite PhosphoSite-Q5MY95
TrEMBL
UniProt Splice Variant
Entrez Gene 377841
UniGene Hs.512562
RefSeq NP_001028285
HUGO HGNC:24860
OMIM
CCDS CCDS43913
HPRD 16864
IMGT
EMBL AY359088 AY430414 AY903953 AY903954 BC141810 BX322799
GenPept AAI41811 AAQ89446 AAR04374 AAW83515 AAW83516 CAM24777

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca