InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WNT4

Summary

InnateDB Protein

IDBP-93666.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT4

Protein Name

wingless-type MMTV integration site family, member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000290167

InnateDB Gene

IDBG-93664 (WNT4)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]: A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. {ECO:0000269PubMed:18179883}. Note=The disease is caused by mutations affecting the gene represented in this entry.Mullerian aplasia and hyperandrogenism (MULLAPL) [MIM:158330]: A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism. {ECO:0000269PubMed:15317892, ECO:0000269PubMed:16959810, ECO:0000269PubMed:18182450}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0048018	receptor agonist activity

Biological Process

GO:0001656	metanephros development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0001837	epithelial to mesenchymal transition
GO:0001838	embryonic epithelial tube formation
GO:0001889	liver development
GO:0006702	androgen biosynthetic process
GO:0007275	multicellular organismal development
GO:0007276	gamete generation
GO:0007548	sex differentiation
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009267	cellular response to starvation
GO:0010629	negative regulation of gene expression
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016055	Wnt signaling pathway
GO:0018345	protein palmitoylation
GO:0022407	regulation of cell-cell adhesion
GO:0030154	cell differentiation
GO:0030182	neuron differentiation
GO:0030237	female sex determination
GO:0030325	adrenal gland development
GO:0030336	negative regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0032321	positive regulation of Rho GTPase activity
GO:0032349	positive regulation of aldosterone biosynthetic process
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033077	T cell differentiation in thymus
GO:0033080	immature T cell proliferation in thymus
GO:0035239	tube morphogenesis
GO:0035567	non-canonical Wnt signaling pathway
GO:0038030	non-canonical Wnt receptor signaling pathway via MAPK cascade
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042445	hormone metabolic process
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045836	positive regulation of meiosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048599	oocyte development
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048856	anatomical structure development
GO:0051145	smooth muscle cell differentiation
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0060070	canonical Wnt signaling pathway
GO:0060126	somatotropin secreting cell differentiation
GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
GO:0060231	mesenchymal to epithelial transition
GO:0060748	tertiary branching involved in mammary gland duct morphogenesis
GO:0060993	kidney morphogenesis
GO:0061045	negative regulation of wound healing
GO:0061180	mammary gland epithelium development
GO:0061184	positive regulation of dermatome development
GO:0061205	paramesonephric duct development
GO:0061369	negative regulation of testicular blood vessel morphogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0072033	renal vesicle formation
GO:0072034	renal vesicle induction
GO:0072162	metanephric mesenchymal cell differentiation
GO:0072164	mesonephric tubule development
GO:0072174	metanephric tubule formation
GO:0072210	metanephric nephron development
GO:0072273	metanephric nephron morphogenesis
GO:0090002	establishment of protein localization to plasma membrane
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000019	negative regulation of male gonad development
GO:2000066	positive regulation of cortisol biosynthetic process
GO:2000225	negative regulation of testosterone biosynthetic process
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0031012	extracellular matrix