InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRNPR

Summary

InnateDB Protein

IDBP-93847.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPR

Protein Name

heterogeneous nuclear ribonucleoprotein R

Synonyms

hnRNP-R; HNRPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000363745

InnateDB Gene

IDBG-93845 (HNRNPR)

Protein Structure

UniProt Annotation

Function

Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an important role in processing of precursor mRNA in the nucleus.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 162 experimentally validated interaction(s) in this database.

Experimentally validated
Total	162 [view]
Protein-Protein	160 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome