Version 5.4
Homo sapiens Protein: PSD3
Summary
InnateDB Protein IDBP-9405.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSD3
Protein Name pleckstrin and Sec7 domain containing 3
Synonyms EFA6R; HCA67;
Species Homo sapiens
Ensembl Protein ENSP00000286485
InnateDB Gene IDBG-9403 (PSD3)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor for ARF6. {ECO:0000250}.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 2 is expressed in epididymis (at protein level). {ECO:0000269PubMed:20736409}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
Biological Process
GO:0030182 neuron differentiation
GO:0032012 regulation of ARF protein signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR000904 Sec7 domain
IPR001605 Pleckstrin homology domain, spectrin-type
IPR001849 Pleckstrin homology domain
PFAM PF01369
PF00169
PRINTS PR00683
PIRSF
SMART SM00222
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NYI0
PhosphoSite PhosphoSite-Q9NYI0
TrEMBL E5RJE4
UniProt Splice Variant
Entrez Gene 23362
UniGene Hs.600917
RefSeq NP_996792
HUGO HGNC:19093
OMIM 614440
CCDS CCDS34854
HPRD 11462
IMGT
EMBL AB023159 AC009884 AC087821 AC090420 AC100800 AC100849 AC120051 AF243495 AF519767 BC075044 BC075045 GU727648
GenPept AAF61269 AAH75044 AAH75045 AAM74203 ADU87649 BAA76786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca