InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR1E

Summary

InnateDB Protein

IDBP-94076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR1E

Protein Name

5-hydroxytryptamine (serotonin) receptor 1E

Synonyms

5-HT1E;

Species

Homo sapiens

Ensembl Protein

ENSP00000307766

InnateDB Gene

IDBG-94074 (HTR1E)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:14744596, ECO:0000269PubMed:1513320, ECO:0000269PubMed:1608964, ECO:0000269PubMed:1733778, ECO:0000269PubMed:21422162}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14744596, ECO:0000269PubMed:1513320, ECO:0000269PubMed:1608964, ECO:0000269PubMed:1733778, ECO:0000269PubMed:21422162}; Multi- pass membrane protein {ECO:0000269PubMed:14744596, ECO:0000269PubMed:1513320, ECO:0000269PubMed:1608964, ECO:0000269PubMed:1733778, ECO:0000269PubMed:21422162}.

Disease Associations

Tissue Specificity

Detected in brain. {ECO:0000269PubMed:14744596}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0051378	serotonin binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0030815	negative regulation of cAMP metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28566