InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF593

Summary

InnateDB Protein

IDBP-94487.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF593

Protein Name

zinc finger protein 593

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363384

InnateDB Gene

IDBG-94485 (ZNF593)

Protein Structure

UniProt Annotation

Function

Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding