InnateDB Protein
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IDBP-9450.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SREBF2
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Protein Name
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sterol regulatory element binding transcription factor 2
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Synonyms
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bHLHd2; SREBP-2; SREBP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354476
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InnateDB Gene
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IDBG-9448 (SREBF2)
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Protein Structure
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Function |
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes. {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.Processed sterol regulatory element-binding protein 2: Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed in adult and fetal tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
81
[view]
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Protein-Protein |
73
[view]
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Protein-DNA |
7
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
1
[view]
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006629
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lipid metabolic process
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GO:0008203
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cholesterol metabolic process
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GO:0010886
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positive regulation of cholesterol storage
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0055098
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response to low-density lipoprotein particle stimulus
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GO:0071499
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cellular response to laminar fluid shear stress
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GO:0072368
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regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
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GO:0090370
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negative regulation of cholesterol efflux
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GO:2000188
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regulation of cholesterol homeostasis
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q12772
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PhosphoSite |
PhosphoSite-Q12772
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TrEMBL |
Q8NCY3
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UniProt Splice Variant |
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Entrez Gene |
6721
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UniGene |
Hs.443258
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RefSeq |
NP_004590
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HUGO |
HGNC:11290
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OMIM |
600481
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CCDS |
CCDS14023
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HPRD |
02726
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IMGT |
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EMBL |
AL021453
AL834221
BC051385
BC051799
BC056158
CH471095
CT841522
U02031
Z99716
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GenPept |
AAA50746
AAH51385
AAH51799
AAH56158
CAD38902
CAI22917
CAI41688
CAJ86452
EAW60469
EAW60471
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