Homo sapiens Protein: IL6
InnateDB Protein IDBP-9464.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL6
Protein Name interleukin 6 (interferon, beta 2)
Synonyms BSF2; HGF; HSF; IFNB2; IL-6;
Species Homo sapiens
Ensembl Protein ENSP00000258743
InnateDB Gene IDBG-9462 (IL6)
Protein Structure
UniProt Annotation
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Subcellular Localization Secreted.
Disease Associations Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 12 [view]
Protein-DNA 18 [view]
Protein-RNA 0
RNA-RNA 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005138 interleukin-6 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001781 neutrophil apoptotic process
GO:0002384 hepatic immune response
GO:0002446 neutrophil mediated immunity
GO:0002548 monocyte chemotaxis
GO:0002675 positive regulation of acute inflammatory response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0008284 positive regulation of cell proliferation
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010888 negative regulation of lipid storage
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0031018 endocrine pancreas development
GO:0031175 neuron projection development
GO:0032494 response to peptidoglycan
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042102 positive regulation of T cell proliferation
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045079 negative regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045599 negative regulation of fat cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051024 positive regulation of immunoglobulin secretion
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0051607 defense response to virus
GO:0070091 glucagon secretion
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0072540 T-helper 17 cell lineage commitment
GO:2000366 positive regulation of STAT protein import into nucleus
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005896 interleukin-6 receptor complex
Protein Structure and Domains
InterPro IPR003573 Interleukin-6/Interleukin-23/GCSF/MGF
IPR003574 Interleukin-6
IPR009079 Four-helical cytokine-like, core
PFAM PF00489
Post-translational Modifications
SwissProt P05231
PhosphoSite PhosphoSite-P05231
UniProt Splice Variant
Entrez Gene 3569
RefSeq NP_000591
OMIM 147620
HPRD 00970
EMBL AC073072 AF372214 BC015511 BT019748 BT019749 CH236948 CH471073 CR450296 JQ250825 M14584 M18403 M29150 M54894 S56892 X04402 X04403 X04430 X04602 Y00081
GenPept AAA52728 AAA52729 AAA59154 AAC41704 AAD13886 AAH15511 AAK48987 AAS07539 AAV38553 AAV38554 AFF18412 CAA27990 CAA27991 CAA28026 CAA28268 CAA68278 CAG29292 EAL24265 EAW93756 EAW93758