Version 5.4
Homo sapiens Protein: TOMM7
Summary
InnateDB Protein IDBP-9512.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOMM7
Protein Name translocase of outer mitochondrial membrane 7 homolog (yeast)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000351214
InnateDB Gene IDBG-9510 (TOMM7)
Protein Structure
UniProt Annotation
Function Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. {ECO:0000269PubMed:18331822, ECO:0000269PubMed:24270810}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:12198123}; Single-pass membrane protein {ECO:0000269PubMed:12198123}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008320 protein transmembrane transporter activity
Biological Process
GO:0006626 protein targeting to mitochondrion
GO:0030150 protein import into mitochondrial matrix
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005742 mitochondrial outer membrane translocase complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR012621 Mitochondrial import receptor subunit TOM7
PFAM PF08038
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0U1
PhosphoSite PhosphoSite-Q9P0U1
TrEMBL Q75MR5
UniProt Splice Variant
Entrez Gene 54543
UniGene
RefSeq NP_061932
HUGO HGNC:21648
OMIM 607980
CCDS CCDS5376
HPRD 16266
IMGT
EMBL AC005682 AF150733 AJ011007 BC001732 BC071973 CH471073 CR456960
GenPept AAF67473 AAH01732 AAH71973 AAS01992 CAB38060 CAG33241 EAW93761

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca