Version 5.4
Homo sapiens Protein: GMEB1
Summary
InnateDB Protein IDBP-95286.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMEB1
Protein Name glucocorticoid modulatory element binding protein 1
Synonyms P96PIF; PIF96;
Species Homo sapiens
Ensembl Protein ENSP00000355186
InnateDB Gene IDBG-95280 (GMEB1)
Protein Structure
UniProt Annotation
Function Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Subcellular Localization Nucleus. Cytoplasm. Note=May be also cytoplasmic.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000770 SAND domain
IPR010919 SAND domain-like
PFAM PF01342
PRINTS
PIRSF
SMART SM00258
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y692
PhosphoSite PhosphoSite-Q9Y692
TrEMBL B1AT47
UniProt Splice Variant
Entrez Gene 10691
UniGene Hs.713771
RefSeq
HUGO HGNC:4370
OMIM 604409
CCDS CCDS328
HPRD 16059
IMGT
EMBL AF099013 AF173868 AF203694 AK000892 AK315436 AL645729 BC001473 CH471059
GenPept AAD39355 AAD51352 AAG01189 AAH01473 BAA91410 BAG37824 CAH72427 EAX07676 EAX07677 EAX07678 EAX07679

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca