InnateDB Protein
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IDBP-95289.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AMD1
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Protein Name
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adenosylmethionine decarboxylase 1
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Synonyms
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ADOMETDC; AMD; SAMDC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357880
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InnateDB Gene
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IDBG-95287 (AMD1)
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Protein Structure
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Function |
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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|
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Molecular Function |
Accession |
GO Term |
GO:0004014
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adenosylmethionine decarboxylase activity
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GO:0019810
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putrescine binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001985
S-adenosylmethionine decarboxylase
IPR016067
S-adenosylmethionine decarboxylase, core
IPR018167
S-adenosylmethionine decarboxylase subgroup
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PFAM |
PF01536
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PRINTS |
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PIRSF |
PIRSF001355
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P17707
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PhosphoSite |
PhosphoSite-P17707
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TrEMBL |
Q5VXN5
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UniProt Splice Variant |
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Entrez Gene |
262
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UniGene |
Hs.652196
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RefSeq |
NP_001625
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HUGO |
HGNC:457
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OMIM |
180980
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CCDS |
CCDS5086
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HPRD |
01622
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IMGT |
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EMBL |
AK304351
AK316471
AL357515
AL365206
AL832698
BC000171
CH471051
M21154
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GenPept |
AAA51716
AAH00171
BAG65194
BAH14842
CAH73388
CAH73390
CAI23233
CAI23235
CAI46113
EAW48307
EAW48308
EAW48309
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