InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMD1

Summary

InnateDB Protein

IDBP-95291.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMD1

Protein Name

adenosylmethionine decarboxylase 1

Synonyms

ADOMETDC; AMD; SAMDC;

Species

Homo sapiens

Ensembl Protein

ENSP00000357877

InnateDB Gene

IDBG-95287 (AMD1)

Protein Structure

UniProt Annotation

Function

Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004014	adenosylmethionine decarboxylase activity

Biological Process

GO:0006557	S-adenosylmethioninamine biosynthetic process
GO:0006595	polyamine metabolic process
GO:0006597	spermine biosynthetic process
GO:0008295	spermidine biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process