InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SDC3

Summary

InnateDB Protein

IDBP-95391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SDC3

Protein Name

syndecan 3

Synonyms

SDCN; SYND3;

Species

Homo sapiens

Ensembl Protein

ENSP00000344468

InnateDB Gene

IDBG-95385 (SDC3)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. {ECO:0000250, ECO:0000269PubMed:11527150}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in the nervous system, the adrenal gland, and the spleen. {ECO:0000269PubMed:11527150}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0005975	carbohydrate metabolic process
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006027	glycosaminoglycan catabolic process
GO:0007603	phototransduction, visible light
GO:0030198	extracellular matrix organization
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0044281	small molecule metabolic process