InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YARS

Summary

InnateDB Protein

IDBP-95802.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YARS

Protein Name

tyrosyl-tRNA synthetase

Synonyms

CMTDIC; TYRRS; YRS; YTS;

Species

Homo sapiens

Ensembl Protein

ENSP00000362576

InnateDB Gene

IDBG-95800 (YARS)

Protein Structure

UniProt Annotation

Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16429158}.

Disease Associations

Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC) [MIM:608323]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. {ECO:0000269PubMed:16429158}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004831	tyrosine-tRNA ligase activity
GO:0004871	signal transducer activity
GO:0005153	interleukin-8 receptor binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006418	tRNA aminoacylation for protein translation
GO:0006437	tyrosyl-tRNA aminoacylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0010467	gene expression