Version 5.4
Homo sapiens Protein: FNDC5
Summary
InnateDB Protein IDBP-95821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FNDC5
Protein Name fibronectin type III domain containing 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362570
InnateDB Gene IDBG-95819 (FNDC5)
Protein Structure
UniProt Annotation
Function Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue. {ECO:0000269PubMed:24040023}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:22237023}; Single-pass type I membrane protein {ECO:0000269PubMed:22237023}. Peroxisome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Imported in peroxisomes through the PEX5 receptor pathway. {ECO:0000250}.Irisin: Secreted. Note=Detected in the blood of individuals subjected to endurance exercise. {ECO:0000269PubMed:22237023}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. {ECO:0000269PubMed:24040023}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0014850 response to muscle activity
GO:0090336 positive regulation of brown fat cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
PFAM PF00041
PF01108
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q8NAU1
TrEMBL
UniProt Splice Variant
Entrez Gene 252995
UniGene Hs.666615
RefSeq NP_715637
HUGO HGNC:20240
OMIM 611906
CCDS CCDS369
HPRD 17009
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca