Version 5.4
Homo sapiens Protein: ASF1A
Summary
InnateDB Protein IDBP-95918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASF1A
Protein Name ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
Synonyms CGI-98; CIA; HSPC146;
Species Homo sapiens
Ensembl Protein ENSP00000229595
InnateDB Gene IDBG-95914 (ASF1A)
Protein Structure
UniProt Annotation
Function Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269PubMed:10759893, ECO:0000269PubMed:11897662, ECO:0000269PubMed:12842904, ECO:0000269PubMed:14718166, ECO:0000269PubMed:15621527, ECO:0000269PubMed:15664198, ECO:0000269PubMed:16151251}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11897662, ECO:0000269PubMed:12842904}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12842904}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0006281 DNA repair
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0031936 negative regulation of chromatin silencing
GO:0042692 muscle cell differentiation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR006818 Histone chaperone, ASF1-like
PFAM PF04729
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y294
PhosphoSite PhosphoSite-Q9Y294
TrEMBL
UniProt Splice Variant
Entrez Gene 25842
UniGene Hs.292316
RefSeq NP_054753
HUGO HGNC:20995
OMIM 609189
CCDS CCDS47469
HPRD 16459
IMGT
EMBL AB028628 AC022098 AF151856 AF161495 AF279306 AK025738 AL050261 BC010878 CR457347
GenPept AAD34093 AAF29110 AAH10878 AAK82972 BAA96542 BAB15228 CAB43363 CAG33628

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca