InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHC2

Summary

InnateDB Protein

IDBP-95932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHC2

Protein Name

polyhomeotic homolog 2 (Drosophila)

Synonyms

EDR2; HPH2; PH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000362517

InnateDB Gene

IDBG-95922 (PHC2)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21282530}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0007275

multicellular organismal development

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR003118 Pointed domain
IPR011510 Sterile alpha motif, type 2
IPR012313 Zinc finger, FCS-type
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF02198
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00251

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IXK0