Version 5.4
Homo sapiens Protein: DLGAP3
Summary
InnateDB Protein IDBP-96040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLGAP3
Protein Name discs, large (Drosophila) homolog-associated protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000235180
InnateDB Gene IDBG-96036 (DLGAP3)
Protein Structure
UniProt Annotation
Function May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007267 cell-cell signaling
Cellular Component
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR005026 Guanylate-kinase-associated protein
PFAM PF03359
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95886
PhosphoSite PhosphoSite-O95886
TrEMBL B4DH33
UniProt Splice Variant
Entrez Gene 58512
UniGene Hs.733945
RefSeq NP_001073887
HUGO HGNC:30368
OMIM 611413
CCDS CCDS30670
HPRD
IMGT
EMBL AC114490 AF131778 AK294907 AL122010
GenPept AAD20042 BAG57994 CAI23556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca