Version 5.4
| Homo sapiens Protein: CLVS2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-96060.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CLVS2 | ||||||||
| Protein Name | clavesin 2 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000275162 | ||||||||
| InnateDB Gene | IDBG-96058 (CLVS2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269PubMed:19651769}. | ||||||||
| Subcellular Localization | Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269PubMed:19651769}; Peripheral membrane protein {ECO:0000269PubMed:19651769}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001071
Cellular retinaldehyde binding/alpha-tocopherol transport IPR001251 CRAL-TRIO domain IPR011074 CRAL/TRIO, N-terminal domain |
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| PFAM |
PF00650
PF13716 PF03765 |
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| PRINTS |
PR00180
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| PIRSF | |||||||||
| SMART |
SM00516
SM01100 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q5SYC1 | ||||||||
| PhosphoSite | PhosphoSite-Q5SYC1 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 134829 | ||||||||
| UniGene | Hs.486361 | ||||||||
| RefSeq | NP_001010852 | ||||||||
| HUGO | HGNC:23046 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS34525 | ||||||||
| HPRD | 16666 | ||||||||
| IMGT | |||||||||
| EMBL | AK095527 AK295158 AL591428 BC101376 BC101377 BK006900 CH471051 DC324799 | ||||||||
| GenPept | AAI01377 AAI01378 BAG53077 BAG58172 CAI12306 CAI12307 DAA06537 EAW48161 | ||||||||