Version 5.4
Homo sapiens Protein: CLVS2
Summary
InnateDB Protein IDBP-96062.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLVS2
Protein Name clavesin 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357423
InnateDB Gene IDBG-96058 (CLVS2)
Protein Structure
UniProt Annotation
Function Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269PubMed:19651769}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269PubMed:19651769}; Peripheral membrane protein {ECO:0000269PubMed:19651769}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Biological Process
GO:0006810 transport
GO:0007040 lysosome organization
Cellular Component
GO:0005768 endosome
GO:0005802 trans-Golgi network
GO:0030136 clathrin-coated vesicle
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
IPR001251 CRAL-TRIO domain
PFAM PF00650
PF13716
PRINTS PR00180
PIRSF
SMART SM00516
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SYC1
PhosphoSite PhosphoSite-Q5SYC1
TrEMBL
UniProt Splice Variant
Entrez Gene 134829
UniGene Hs.486361
RefSeq
HUGO HGNC:23046
OMIM
CCDS
HPRD 16666
IMGT
EMBL AK095527 AK295158 AL591428 BC101376 BC101377 BK006900 CH471051 DC324799
GenPept AAI01377 AAI01378 BAG53077 BAG58172 CAI12306 CAI12307 DAA06537 EAW48161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca