InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF2C1

Summary

InnateDB Protein

IDBP-96238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2C1

Protein Name

eukaryotic translation initiation factor 2C, 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362300

InnateDB Gene

IDBG-96234 (EIF2C1)

Protein Structure

UniProt Annotation

Function

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). {ECO:0000269PubMed:16289642, ECO:0000269PubMed:16936728, ECO:0000269PubMed:18771919}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000269PubMed:16289642, ECO:0000269PubMed:20616046}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005844	polysome
GO:0030529	ribonucleoprotein complex
GO:0035068	micro-ribonucleoprotein complex