Version 5.4
Homo sapiens Protein: TEKT2
Summary
InnateDB Protein IDBP-96273.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TEKT2
Protein Name tektin 2 (testicular)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000207457
InnateDB Gene IDBG-96269 (TEKT2)
Protein Structure
UniProt Annotation
Function Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). {ECO:0000250}.
Subcellular Localization Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Note=In sperm, observed in a discontinuous punctate pattern in the flagellum and in the postacrosomal head region.
Disease Associations
Tissue Specificity Expressed at high levels in testis, trachea and fetal lung, and at lower levels in ovary, pituitary, adult lung, fetal brain and fetal kidney. {ECO:0000269PubMed:11751288}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0030030 cell projection organization
GO:0030317 sperm motility
GO:0036159 inner dynein arm assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005929 cilium
Protein Structure and Domains
PDB ID
InterPro IPR000435 Tektin
IPR009053 Prefoldin
PFAM
PRINTS PR00511
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UIF3
PhosphoSite PhosphoSite-Q9UIF3
TrEMBL
UniProt Splice Variant
Entrez Gene 27285
UniGene Hs.127111
RefSeq NP_055281
HUGO HGNC:11725
OMIM 608953
CCDS CCDS401
HPRD 16410
IMGT
EMBL AB033823 AF054910 AL138787 BC035620 CH471059
GenPept AAC09343 AAH35620 BAA89350 CAC21454 EAX07392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca