InnateDB Protein
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IDBP-96297.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ADPRHL2
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Protein Name
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ADP-ribosylhydrolase like 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362273
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InnateDB Gene
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IDBG-96295 (ADPRHL2)
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Protein Structure
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Function |
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP- ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. {ECO:0000269PubMed:16278211}.
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Subcellular Localization |
Cytoplasm. Mitochondrion matrix. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:16278211}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005502
ADP-ribosylation/Crystallin J1
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PFAM |
PF03747
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NX46
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PhosphoSite |
PhosphoSite-Q9NX46
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TrEMBL |
B7ZAN4
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UniProt Splice Variant |
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Entrez Gene |
54936
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UniGene |
Hs.18021
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RefSeq |
NP_060295
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HUGO |
HGNC:21304
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OMIM |
610624
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CCDS |
CCDS402
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HPRD |
12432
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IMGT |
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EMBL |
AF212236
AJ313333
AJ427295
AK000453
AK223037
AK295283
AK316349
AL138787
BC014169
CH471059
CR457237
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GenPept |
AAH14169
AAK14922
BAA91174
BAD96757
BAG58267
BAH14720
CAC21453
CAC85940
CAD20316
CAG33518
EAX07389
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