Version 5.4
Homo sapiens Protein: STK40
Summary
InnateDB Protein IDBP-96355.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK40
Protein Name serine/threonine kinase 40
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362221
InnateDB Gene IDBG-96349 (STK40)
Protein Structure
UniProt Annotation
Function May be a negative regulator of NF-kappa-B and p53- mediated gene transcription. {ECO:0000269PubMed:13679039}.
Subcellular Localization Nucleus {ECO:0000269PubMed:13679039}. Cytoplasm {ECO:0000269PubMed:13679039}.
Disease Associations
Tissue Specificity Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269PubMed:13679039}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N2I9
PhosphoSite PhosphoSite-Q8N2I9
TrEMBL
UniProt Splice Variant
Entrez Gene 83931
UniGene Hs.729647
RefSeq NP_114406
HUGO HGNC:21373
OMIM 609437
CCDS CCDS407
HPRD 11359
IMGT
EMBL AK024504 AK075029 AK075048 AK131560 AL591845 AL834137 AY198395 BC005169 BC007835 BC008344 CH471059
GenPept AAH05169 AAH07835 AAH08344 AAP20040 BAB15794 BAC11361 BAC11371 BAD18694 CAD38852 CAH71862 CAH71863 CAH71864 EAX07371 EAX07373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca