InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IPO13

Summary

InnateDB Protein

IDBP-97612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IPO13

Protein Name

importin 13

Synonyms

IMP13; KAP13; LGL2; RANBP13;

Species

Homo sapiens

Ensembl Protein

ENSP00000361418

InnateDB Gene

IDBG-97610 (IPO13)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. {ECO:0000250, ECO:0000269PubMed:11447110, ECO:0000269PubMed:15143176}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269PubMed:10745026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.