InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UST

Summary

InnateDB Protein

IDBP-97686.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UST

Protein Name

uronyl-2-sulfotransferase

Synonyms

2OST;

Species

Homo sapiens

Ensembl Protein

ENSP00000356433

InnateDB Gene

IDBG-97684 (UST)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10187838}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001733	galactosylceramide sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006477	protein sulfation
GO:0009058	biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030208	dermatan sulfate biosynthetic process
GO:0044281	small molecule metabolic process