InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUP43

Summary

InnateDB Protein

IDBP-97782.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUP43

Protein Name

nucleoporin 43kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342262

InnateDB Gene

IDBG-97774 (NUP43)

Protein Structure

UniProt Annotation

Function

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269PubMed:17363900}.

Subcellular Localization

Chromosome, centromere, kinetochore. Nucleus, nuclear pore complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0005975	carbohydrate metabolic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007077	mitotic nuclear envelope disassembly
GO:0008645	hexose transport
GO:0010827	regulation of glucose transport
GO:0015031	protein transport
GO:0015758	glucose transport
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0044281	small molecule metabolic process
GO:0051028	mRNA transport
GO:0055085	transmembrane transport