Version 5.4
Homo sapiens Protein: LRRC41
Summary
InnateDB Protein IDBP-98103.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC41
Protein Name leucine rich repeat containing 41
Synonyms MUF1;
Species Homo sapiens
Ensembl Protein ENSP00000343298
InnateDB Gene IDBG-98101 (LRRC41)
Protein Structure
UniProt Annotation
Function Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:15601820}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
PFAM
PRINTS
PIRSF
SMART SM00368
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15345
PhosphoSite PhosphoSite-Q15345
TrEMBL
UniProt Splice Variant
Entrez Gene 10489
UniGene Hs.144941
RefSeq NP_006360
HUGO HGNC:16917
OMIM
CCDS CCDS533
HPRD 10102
IMGT
EMBL AF370430 AK125827 AK291283 AK297596 AL121602 AL122001 BC004953 BC101522 BC101524 BX537366 CH471059 X86018
GenPept AAH04953 AAI01523 AAI01525 AAQ15266 BAC86308 BAF83972 BAG59981 CAA60013 CAD97609 CAI21964 CAI22118 EAX06927

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca