InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MPP5

Summary

InnateDB Protein

IDBP-9830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP5

Protein Name

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261681

InnateDB Gene

IDBG-9828 (MPP5)

Protein Structure

UniProt Annotation

Function

May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon.

Disease Associations

Tissue Specificity

Expressed in the retina (at protein level). {ECO:0000269PubMed:15558731, ECO:0000269PubMed:15914641}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0007009	plasma membrane organization
GO:0032287	peripheral nervous system myelin maintenance
GO:0032288	myelin assembly
GO:0034329	cell junction assembly
GO:0035750	protein localization to myelin sheath abaxonal region
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0012505	endomembrane system
GO:0035749	myelin sheath adaxonal region
GO:0043219	lateral loop
GO:0043220	Schmidt-Lanterman incisure
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR015145 L27-N
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM