Version 5.4
Homo sapiens Protein: ELAVL4
Summary
InnateDB Protein IDBP-98373.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELAVL4
Protein Name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
Synonyms HUD; PNEM;
Species Homo sapiens
Ensembl Protein ENSP00000360889
InnateDB Gene IDBG-98367 (ELAVL4)
Protein Structure
UniProt Annotation
Function May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA. {ECO:0000250, ECO:0000269PubMed:10710437, ECO:0000269PubMed:7898713}.
Subcellular Localization
Disease Associations
Tissue Specificity Brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0017091 AU-rich element binding
Biological Process
GO:0006396 RNA processing
GO:0006397 mRNA processing
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR002343 Paraneoplastic encephalomyelitis antigen
IPR006548 Splicing factor ELAV/HuD
PFAM PF00076
PRINTS PR00961
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26378
PhosphoSite PhosphoSite-P26378
TrEMBL B7Z5E0
UniProt Splice Variant
Entrez Gene 1996
UniGene Hs.604385
RefSeq NP_001138246
HUGO HGNC:3315
OMIM 168360
CCDS CCDS44140
HPRD 01343
IMGT
EMBL AK297338 AK298817 AL583843 AL592182 AL645730 AL731870 AY033995 AY033996 AY033997 AY033998 BC036071 CH471059 M62843
GenPept AAA58396 AAH36071 AAK57538 AAK57539 AAK57540 AAK57541 BAH12553 BAH12876 CAI14634 CAI14635 CAI14636 CAI14637 CAI15788 CAI15789 CAI15790 CAI15791 EAX06845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca