Homo sapiens Protein: SLC22A1
InnateDB Protein IDBP-98658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A1
Protein Name solute carrier family 22 (organic cation transporter), member 1
Synonyms HOCT1; OCT1; oct1_cds;
Species Homo sapiens
Ensembl Protein ENSP00000355930
InnateDB Gene IDBG-98656 (SLC22A1)
Protein Structure
UniProt Annotation
Function Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase. {ECO:0000269PubMed:11388889, ECO:0000269PubMed:11408531, ECO:0000269PubMed:15389554, ECO:0000269PubMed:16272756, ECO:0000269PubMed:16581093, ECO:0000269PubMed:9187257, ECO:0000269PubMed:9260930, ECO:0000269PubMed:9655880}.
Subcellular Localization Basolateral cell membrane {ECO:0000269PubMed:16263091}; Multi-pass membrane protein {ECO:0000269PubMed:16263091}.
Disease Associations
Tissue Specificity Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. {ECO:0000269PubMed:11388889, ECO:0000269PubMed:9187257, ECO:0000269PubMed:9260930}.
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005277 acetylcholine transmembrane transporter activity
GO:0005329 dopamine transmembrane transporter activity
GO:0005333 norepinephrine transmembrane transporter activity
GO:0005515 protein binding
GO:0008504 monoamine transmembrane transporter activity
GO:0008513 secondary active organic cation transmembrane transporter activity
GO:0015075 ion transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006812 cation transport
GO:0006836 neurotransmitter transport
GO:0006855 drug transmembrane transport
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0015874 norepinephrine transport
GO:0034220 ion transmembrane transport
GO:0044281 small molecule metabolic process
GO:0048241 epinephrine transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:1901374 acetate ester transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Protein Structure and Domains
InterPro IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
Post-translational Modifications
SwissProt O15245
PhosphoSite PhosphoSite-O15245
UniProt Splice Variant
Entrez Gene 6580
UniGene Hs.117367
RefSeq NP_003048
OMIM 602607
HPRD 04007
EMBL AJ243995 AJ243996 AJ243998 AJ243999 AJ244000 AJ245460 AJ276051 AJ276052 AJ276053 AK289887 AL353625 BC126364 U77086 X98332
GenPept AAB67703 AAI26365 BAF82576 CAA66977 CAB95971 CAH72016