InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PODN

Summary

InnateDB Protein

IDBP-98694.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PODN

Protein Name

podocan

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360555

InnateDB Gene

IDBG-98692 (PODN)

Protein Structure

UniProt Annotation

Function

Negatively regulates cell proliferation and cell migration. {ECO:0000269PubMed:15063725}.

Subcellular Localization

Isoform 1: Secreted, extracellular space, extracellular matrix.Isoform 2: Cytoplasm {ECO:0000305}.Isoform 3: Cytoplasm {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Kidney, heart, liver, pancreas and vascular smooth muscle cells. Also detected in aortic intima (at protein level). {ECO:0000269PubMed:12796502, ECO:0000269PubMed:15063725, ECO:0000269PubMed:20551380}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding

Biological Process

GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00368
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z5L7