Version 5.4
Homo sapiens Protein: SLC1A7
Summary
InnateDB Protein IDBP-98699.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC1A7
Protein Name solute carrier family 1 (glutamate transporter), member 7
Synonyms AAAT; EAAT5;
Species Homo sapiens
Ensembl Protein ENSP00000360549
InnateDB Gene IDBG-98697 (SLC1A7)
Protein Structure
UniProt Annotation
Function Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed primarily in retina. Detectable in liver, heart, muscle and brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0017153 sodium:dicarboxylate symporter activity
Biological Process
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0015813 L-glutamate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001991 Sodium:dicarboxylate symporter
PFAM PF00375
PRINTS PR00173
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00341
PhosphoSite PhosphoSite-O00341
TrEMBL F1T0D2
UniProt Splice Variant
Entrez Gene 6512
UniGene
RefSeq NP_006662
HUGO HGNC:10945
OMIM 604471
CCDS CCDS574
HPRD 09194
IMGT
EMBL AB593059 AL445183 BC012119 BC017242 CH471059 U76362
GenPept AAB53971 AAH12119 AAH17242 BAJ84006 CAH72594 EAX06755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca