Version 5.4
Homo sapiens Protein: DNASE2B
Summary
InnateDB Protein IDBP-99963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE2B
Protein Name deoxyribonuclease II beta
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000359699
InnateDB Gene IDBG-99961 (DNASE2B)
Protein Structure
UniProt Annotation
Function Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation. {ECO:0000269PubMed:11700027, ECO:0000269PubMed:12944971}.
Subcellular Localization Lysosome {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269PubMed:11376952, ECO:0000269PubMed:11700027, ECO:0000269PubMed:12944971}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004520 endodeoxyribonuclease activity
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006309 apoptotic DNA fragmentation
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005764 lysosome
Protein Structure and Domains
PDB ID
InterPro IPR004947 Deoxyribonuclease II
PFAM PF03265
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WZ79
PhosphoSite PhosphoSite-Q8WZ79
TrEMBL Q66K39
UniProt Splice Variant
Entrez Gene 58511
UniGene Hs.129142
RefSeq NP_067056
HUGO HGNC:28875
OMIM 608057
CCDS CCDS44167
HPRD 09728
IMGT
EMBL AF274571 AF333389 AF334602 AL359273 BC080621 CH471097
GenPept AAF76893 AAH80621 AAL34448 AAL34449 CAH73126 CAH73127 EAW73238 EAW73239

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca