Version 5.4
Homo sapiens Gene: CLNK
Summary
InnateDB Gene IDBG-10035.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLNK
Gene Name cytokine-dependent hematopoietic cell linker
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109684
Encoded Proteins
IDBP-10037
cytokine-dependent hematopoietic cell linker
IDBP-362938
cytokine-dependent hematopoietic cell linker
IDBP-484006
cytokine-dependent hematopoietic cell linker
IDBP-484852
cytokine-dependent hematopoietic cell linker
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:10486395-10684865
Strand Reverse strand
Band p16.1
Transcripts
ENST00000226951 ENSP00000226951
ENST00000442825 ENSP00000390744
ENST00000515667 ENSP00000427256
ENST00000507719 ENSP00000427208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039315
View Gene Order
ENSBTAG00000038340
Not yet available
Cross-References
SwissProt
TrEMBL D6RJB9
UniProt Splice Variant
Entrez Gene 116449
UniGene Hs.62772 Hs.678910
RefSeq NM_052964
HUGO HGNC:17438
OMIM 611434
CCDS CCDS47024
HPRD 14720
IMGT
EMBL AC005599 AC084048 AC110768
GenPept
RNA Seq Atlas 116449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca