Version 5.4
Homo sapiens Gene: LPPR4
Summary
InnateDB Gene IDBG-100436.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPPR4
Gene Name Lipid phosphate phosphatase-related protein type 4
Synonyms LPR4; PHP1; PRG-1; PRG1
Species Homo sapiens
Ensembl Gene ENSG00000117600
Encoded Proteins
IDBP-100438
Lipid phosphate phosphatase-related protein type 4
IDBP-100442
Lipid phosphate phosphatase-related protein type 4
IDBP-387069
Lipid phosphate phosphatase-related protein type 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:99263953-99309590
Strand Forward strand
Band p21.3
Transcripts
ENST00000370185 ENSP00000359204
ENST00000370184 ENSP00000359203
ENST00000457765 ENSP00000394913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008195 phosphatidate phosphatase activity
GO:0042577 lipid phosphatase activity
Biological Process
GO:0007409 axonogenesis
GO:0046839 phospholipid dephosphorylation
GO:0048839 inner ear development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044667
View Gene Order
ENSBTAG00000019031
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13245
RefSeq NM_001166252 NM_014839
HUGO
OMIM
CCDS CCDS53347 CCDS757
HPRD 07425
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca