Version 5.4
Homo sapiens Protein: LPPR4
Summary
InnateDB Protein IDBP-100438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LPPR4
Protein Name Lipid phosphate phosphatase-related protein type 4
Synonyms LPR4; PHP1; PRG-1; PRG1;
Species Homo sapiens
Ensembl Protein ENSP00000359204
InnateDB Gene IDBG-100436 (LPPR4)
Protein Structure
UniProt Annotation
Function Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. {ECO:0000269PubMed:12730698}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Specifically expressed in neurons. {ECO:0000269PubMed:12730698}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008195 phosphatidate phosphatase activity
GO:0042577 lipid phosphatase activity
Biological Process
GO:0007409 axonogenesis
GO:0046839 phospholipid dephosphorylation
GO:0048839 inner ear development
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z2D5
PhosphoSite PhosphoSite-Q7Z2D5
TrEMBL
UniProt Splice Variant
Entrez Gene 9890
UniGene Hs.13245
RefSeq NP_055654
HUGO
OMIM 607813
CCDS CCDS757
HPRD 07425
IMGT
EMBL AB007924 AF357013 AF541281 AK056665 AK291369 AL136147 AL139425 AL834390 AY304518 CH471097
GenPept AAO85400 AAP57770 AAP72155 BAA32300 BAB71245 BAF84058 CAD39052 CAI22799 CAI22800 CAI23225 EAW72991 EAW72992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca