Version 5.4
Homo sapiens Gene: VCAM1
Summary
InnateDB Gene IDBG-100525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCAM1
Gene Name vascular cell adhesion molecule 1
Synonyms CD106; INCAM-100
Species Homo sapiens
Ensembl Gene ENSG00000162692
Encoded Proteins
IDBP-100527
vascular cell adhesion molecule 1
IDBP-100529
vascular cell adhesion molecule 1
IDBP-100531
vascular cell adhesion molecule 1
IDBP-100533
vascular cell adhesion molecule 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:100719742-100739045
Strand Forward strand
Band p21.2
Transcripts
ENST00000294728 ENSP00000294728
ENST00000347652 ENSP00000304611
ENST00000370119 ENSP00000359137
ENST00000370115 ENSP00000359133
ENST00000603679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 451 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 451 [view]
Protein-Protein 444 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008131 primary amine oxidase activity
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001666 response to hypoxia
GO:0002526 acute inflammatory response
GO:0002544 chronic inflammatory response
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007507 heart development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0009308 amine metabolic process
GO:0010043 response to zinc ion
GO:0010212 response to ionizing radiation
GO:0016032 viral process
GO:0016337 single organismal cell-cell adhesion
GO:0019221 cytokine-mediated signaling pathway
GO:0022614 membrane to membrane docking
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0032496 response to lipopolysaccharide
GO:0035094 response to nicotine
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042102 positive regulation of T cell proliferation
GO:0045471 response to ethanol
GO:0050776 regulation of immune response
GO:0050901 leukocyte tethering or rolling
GO:0055114 oxidation-reduction process
GO:0060326 cell chemotaxis
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060669 embryonic placenta morphogenesis
GO:0060710 chorio-allantoic fusion
GO:0071333 cellular response to glucose stimulus
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0002102 podosome
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030175 filopodium
GO:0042383 sarcolemma
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027962
View Gene Order
ENSBTAG00000037539
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_25078
Interferon gamma signaling pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05144
Malaria pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
integrin1_pathway
Beta1 integrin cell surface interactions
anthraxpathway
Cellular roles of Anthrax toxin
integrin2_pathway
Beta2 integrin cell surface interactions
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
a4b7_pathway
a4b7 Integrin signaling
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt P19320
TrEMBL F8UU18 F8UV74 G0ZFQ0 G0ZI12 Q68DC4
UniProt Splice Variant
Entrez Gene 7412
UniGene Hs.109225 Hs.708046
RefSeq NM_080682 NM_001078 NM_001199834
HUGO HGNC:12663
OMIM 192225
CCDS CCDS774 CCDS55617 CCDS773
HPRD 01888
IMGT
EMBL AC093428 AF536818 AK291732 AK296692 BC017276 BC068490 BC085003 CH471097 CR749464 JF271680 JF280676 JF907575 JF917093 M30257 M60335 M73255 M92431 X53051
GenPept AAA51917 AAA61269 AAA61270 AAH17276 AAH68490 AAH85003 AAM96190 AEH21939 AEH21940 AEL21381 AEL30503 BAF84421 BAG59286 CAA37218 CAH18296 EAW72950
RNA Seq Atlas 7412

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca