InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vcam1

Summary

InnateDB Gene

IDBG-189855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vcam1

Gene Name

vascular cell adhesion molecule 1

Synonyms

CD106; Vcam-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027962

Encoded Proteins

IDBP-189857

vascular cell adhesion molecule 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162692:
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:116110020-116129688

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029574

ENSMUSP00000029574

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 401 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	401 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001666	response to hypoxia
GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007507	heart development
GO:0007568	aging
GO:0007584	response to nutrient
GO:0009308	amine metabolic process
GO:0010043	response to zinc ion
GO:0010212	response to ionizing radiation
GO:0022614	membrane to membrane docking
GO:0032496	response to lipopolysaccharide
GO:0035094	response to nicotine
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0042102	positive regulation of T cell proliferation
GO:0045471	response to ethanol
GO:0050901	leukocyte tethering or rolling
GO:0055114	oxidation-reduction process
GO:0060326	cell chemotaxis
GO:0060669	embryonic placenta morphogenesis
GO:0060710	chorio-allantoic fusion
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0002102	podosome
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005902	microvillus
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0042383	sarcolemma
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome
GO:0071065	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
GO:0071944	cell periphery