Version 5.4
Homo sapiens Gene: AHCYL1
Summary
InnateDB Gene IDBG-100935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AHCYL1
Gene Name adenosylhomocysteinase-like 1
Synonyms DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA
Species Homo sapiens
Ensembl Gene ENSG00000168710
Encoded Proteins
IDBP-100937
adenosylhomocysteinase-like 1
IDBP-100939
adenosylhomocysteinase-like 1
IDBP-243249
adenosylhomocysteinase-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:109984686-110023741
Strand Forward strand
Band p13.3
Transcripts
ENST00000369799 ENSP00000358814
ENST00000359172 ENSP00000352092
ENST00000393614 ENSP00000377238
ENST00000475081
ENST00000481423
ENST00000469401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
Experimentally validated
Total 105 [view]
Protein-Protein 103 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004013 adenosylhomocysteinase activity
GO:0004455 ketol-acid reductoisomerase activity
GO:0005515 protein binding
GO:0051287 NAD binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006611 protein export from nucleus
GO:0006730 one-carbon metabolic process
GO:0008150 biological_process
GO:0008652 cellular amino acid biosynthetic process
GO:0010765 positive regulation of sodium ion transport
GO:0031440 regulation of mRNA 3'-end processing
GO:0032412 regulation of ion transmembrane transporter activity
GO:0044070 regulation of anion transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027893
View Gene Order
ENSBTAG00000018893
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt O43865
TrEMBL Q9BTL0
UniProt Splice Variant
Entrez Gene 10768
UniGene Hs.743796
RefSeq NM_001242673 NM_001242674 NM_001242675 NM_001242676 NM_006621
HUGO HGNC:344
OMIM 607826
CCDS CCDS55620 CCDS818
HPRD 07613
IMGT
EMBL AF315687 AK303690 AK316110 AL036027 AL049954 AL772411 AU279527 BC003631 BC007576 BC010681 BC016942 BC065254 BC095476 BC110896 BI460083 BK005417 BK005418 CH471122 T19009 U82761
GenPept AAC01960 AAH03631 AAH07576 AAH10681 AAH16942 AAH65254 AAH95476 AAI10897 AAL26869 BAG64680 BAH14481 CAB43223 CAH70965 CAH70966 DAA05762 DAA05763 EAW56426
RNA Seq Atlas 10768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca