InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AHCYL1

Summary

InnateDB Protein

IDBP-100939.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHCYL1

Protein Name

adenosylhomocysteinase-like 1

Synonyms

DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA;

Species

Homo sapiens

Ensembl Protein

ENSP00000352092

InnateDB Gene

IDBG-100935 (AHCYL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in dendritic cells. {ECO:0000269PubMed:11904675}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.

Experimentally validated
Total	105 [view]
Protein-Protein	103 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004013	adenosylhomocysteinase activity
GO:0004455	ketol-acid reductoisomerase activity
GO:0005515	protein binding
GO:0051287	NAD binding

Biological Process

GO:0006730	one-carbon metabolic process
GO:0008150	biological_process
GO:0008652	cellular amino acid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000043 Adenosylhomocysteinase
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR013116 Acetohydroxy acid isomeroreductase, catalytic
IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain

PFAM

PF05221
PF02826
PF07991
PF00670

PRINTS

PIRSF

PIRSF001109

SMART

SM00996
SM00997

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt