Version 5.4
Homo sapiens Gene: NFE2L3
Summary
InnateDB Gene IDBG-10094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFE2L3
Gene Name nuclear factor (erythroid-derived 2)-like 3
Synonyms NRF3
Species Homo sapiens
Ensembl Gene ENSG00000050344
Encoded Proteins
IDBP-10096
nuclear factor (erythroid-derived 2)-like 3
IDBP-806264
nuclear factor, erythroid 2-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
This gene encodes a member of the cap \'n\' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:26152240-26187125
Strand Forward strand
Band p15.2
Transcripts
ENST00000056233 ENSP00000056233
ENST00000607375 ENSP00000475463
ENST00000606261
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029832
View Gene Order
ENSBTAG00000004136
Not yet available
Cross-References
SwissProt Q9Y4A8
TrEMBL
UniProt Splice Variant
Entrez Gene 9603
UniGene Hs.404741
RefSeq NM_004289
HUGO HGNC:7783
OMIM 604135
CCDS CCDS5396
HPRD 09162
IMGT
EMBL AB010812 AC004520 AF133059 AF134891 AF135116 BC049219 BC056142 BC068455
GenPept AAF61404 AAF61415 AAG43275 AAH49219 AAH56142 AAH68455 AAP22344 BAA76288
RNA Seq Atlas 9603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca