InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFE2L3

Summary

InnateDB Protein

IDBP-10096.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2L3

Protein Name

nuclear factor (erythroid-derived 2)-like 3

Synonyms

NRF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000056233

InnateDB Gene

IDBG-10094 (NFE2L3)

Protein Structure

UniProt Annotation

Function

Activates erythroid-specific, globin gene expression.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}.

Disease Associations

Tissue Specificity

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:10037736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter