InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CEPT1

Summary

InnateDB Gene

IDBG-101017.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEPT1

Gene Name

choline/ethanolamine phosphotransferase 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000134255

Encoded Proteins

IDBP-101021

choline/ethanolamine phosphotransferase 1

IDBP-590104

choline/ethanolamine phosphotransferase 1

IDBP-808605

choline/ethanolamine phosphotransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine by the transfer of phosphocholine from CDP-choline to diacylglycerol. The synthesis of phosphatidylethanolamine by ethanolaminephosphotransferase occurs using an analogous reaction. This gene codes for a choline/ethanolaminephosphotransferase. The protein can synthesize either choline- or ethanolamine- containing phospholipids. Two alternatively spliced transcripts encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:111139627-111185102

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000357172	ENSP00000349696
ENST00000498239
ENST00000480324
ENST00000476865
ENST00000460443
ENST00000478042
ENST00000473474
ENST00000467362
ENST00000483427
ENST00000545121	ENSP00000441980
ENST00000615636	ENSP00000477632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004142	diacylglycerol cholinephosphotransferase activity
GO:0004307	ethanolaminephosphotransferase activity
GO:0016780	phosphotransferase activity, for other substituted phosphate groups
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0008654	phospholipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040774

View Gene Order

ENSBTAG00000020169

Not yet available

Pathways

NETPATH

REACTOME

REACT_121238

Synthesis of PC pathway

REACT_120919

Synthesis of PE pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa00565

Ether lipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.363572 Hs.599612 Hs.618766 Hs.634763 Hs.701459

RefSeq

NM_001007794 NM_006090 XM_006710285

HUGO

OMIM

CCDS

CCDS830

HPRD

13024

IMGT

EMBL

GenPept

RNA Seq Atlas