InnateDB Protein
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IDBP-101021.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CEPT1
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Protein Name
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choline/ethanolamine phosphotransferase 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349696
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InnateDB Gene
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IDBG-101017 (CEPT1)
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Protein Structure
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Function |
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity. {ECO:0000269PubMed:10191259, ECO:0000269PubMed:10893425}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:12221122}; Multi-pass membrane protein {ECO:0000269PubMed:12221122}. Nucleus membrane {ECO:0000269PubMed:12221122}; Multi-pass membrane protein {ECO:0000269PubMed:12221122}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:10191259}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004142
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diacylglycerol cholinephosphotransferase activity
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GO:0004307
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ethanolaminephosphotransferase activity
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GO:0016780
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phosphotransferase activity, for other substituted phosphate groups
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000462
CDP-alcohol phosphatidyltransferase
IPR014472
Choline/ethanolamine phosphotransferase
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PFAM |
PF01066
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PRINTS |
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PIRSF |
PIRSF015665
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y6K0
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PhosphoSite |
PhosphoSite-Q9Y6K0
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TrEMBL |
A0A024R0C0
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UniProt Splice Variant |
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Entrez Gene |
10390
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UniGene |
Hs.701459
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RefSeq |
NP_006081
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HUGO |
HGNC:24289
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OMIM |
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CCDS |
CCDS830
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HPRD |
13024
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IMGT |
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EMBL |
AF068302
AF138862
AL355816
AL833102
BC032610
BC049196
CH471122
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GenPept |
AAD25170
AAF61194
AAH32610
AAH49196
CAH10403
CAI19367
EAW56470
EAW56471
EAW56472
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