Version 5.4
Homo sapiens Gene: DCLRE1B
Summary
InnateDB Gene IDBG-101254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1B
Gene Name DNA cross-link repair 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118655
Encoded Proteins
IDBP-101256
DNA cross-link repair 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:113905141-113914086
Strand Forward strand
Band p13.2
Transcripts
ENST00000369563 ENSP00000358576
ENST00000466480
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000723 telomere maintenance
GO:0006281 DNA repair
GO:0031627 telomeric loop formation
GO:0031848 protection from non-homologous end joining at telomere
GO:0031860 telomeric 3' overhang formation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027845
View Gene Order
ENSBTAG00000003616
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.591412
RefSeq NM_022836
HUGO
OMIM
CCDS CCDS866
HPRD 16785
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca