Version 5.4
Mus musculus Gene: Dclre1b
Summary
InnateDB Gene IDBG-181757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dclre1b
Gene Name DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027845
Encoded Proteins
IDBP-181759
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
IDBP-181761
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
IDBP-267941
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
IDBP-267945
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
IDBP-541777
DNA cross-link repair 1B, PSO2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118655:
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:103800605-103809444
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000029435 ENSMUSP00000029435
ENSMUST00000063502 ENSMUSP00000067695
ENSMUST00000106834 ENSMUSP00000102447
ENSMUST00000106832 ENSMUSP00000102445
ENSMUST00000128716 ENSMUSP00000121063
ENSMUST00000147894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0000075 cell cycle checkpoint
GO:0000723 telomere maintenance
GO:0006289 nucleotide-excision repair
GO:0031627 telomeric loop formation
GO:0031848 protection from non-homologous end joining at telomere
GO:0031860 telomeric 3' overhang formation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118655
View Gene Order
ENSBTAG00000003616
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.374850 Mm.412294
RefSeq NM_001025312 NM_133865
OMIM
CCDS CCDS17694 CCDS17695
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca