Version 5.4
Homo sapiens Gene: SIKE1
Summary
InnateDB Gene IDBG-101319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIKE1
Gene Name suppressor of IKBKE 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000052723
Encoded Proteins
IDBP-101321
suppressor of IKBKE 1
IDBP-101325
suppressor of IKBKE 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16281057
RP5-1000E10.4 (SIKE) is a physiological suppressor of IKKepsilon and TBK1 and plays an inhibitory role in virus- and TLR3-triggered IRF3 but not NF-kappaB activation pathways.
Entrez Gene
Summary SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:114769479-114780685
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369528 ENSP00000358541
ENST00000060969 ENSP00000060969
ENST00000369524
ENST00000510745
ENST00000506320
ENST00000462123
ENST00000475335
ENST00000466657
ENST00000474562
ENST00000471969
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027854
View Gene Order
ENSBTAG00000015977
Not yet available
Pathways
NETPATH
REACTOME
REACT_24938
TRAF6 mediated IRF7 activation pathway
REACT_25026
TRAF3-dependent IRF activation pathway pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04622
RIG-I-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602337 Hs.709277
RefSeq NM_001102396 NM_025073
HUGO
OMIM
CCDS CCDS41371 CCDS878
HPRD 07958
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca